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Cells and viruses HeLa H1 or HeLa R19 cells were maintained in Dubecco's modified Eagle's medium (DMEM) (Life Technology) supplemented with 8% bovine calf serum (Thermo Scientific), 100 units/ml of penicillin-streptomycin (Life Technology)

INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II

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near research site (if localized SubQ modeling possible) or systemic administration for broader studies Cycle length: 46 weeks on for acute injury models (extend to 8 weeks if needed for chronic issues), followed by 24 weeks off to reset sensitivity Use strictly according to the manufacturers directions